Since the emergence of COVID-19, caused by the novel coronavirus SARS-CoV-2, the medical community has uncovered a wide spectrum of symptoms beyond the commonly known fever, cough, and respiratory distress.
One lesser-known but increasingly reported symptom is mouth pain, which encompasses sore throat, oral ulcers, dry mouth, and other oral discomforts. This article explores the potential causes, symptoms, and management strategies for mouth pain associated with COVID-19/Mouth Pain Covid.
How Does COVID-19 Affect the Mouth?

COVID-19 primarily targets the respiratory system, but it can also manifest symptoms throughout the body. The virus binds to ACE2 receptors—found abundantly in the respiratory tract, but also in the oral mucosa, salivary glands, and tongue. This receptor distribution helps explain why many patients experience oral symptoms.
Common Oral and Mouth-Related Symptoms in COVID-19
- Sore Throat: One of the earliest and most frequent symptoms is a sore or scratchy throat. This discomfort can range from mild irritation to severe pain, making swallowing difficult.
- Oral Ulcers: Some COVID-19 patients develop painful ulcers or blisters inside their mouths. These lesions may resemble canker sores and can contribute to mouth pain and difficulty eating or drinking.
- Dry Mouth (Xerostomia): Infection and inflammation of the salivary glands, or side effects from medications used to treat COVID-19, can reduce saliva production. Reduced saliva leads to dry mouth, which can cause discomfort, increased risk of tooth decay, and difficulties speaking or swallowing.
- Altered Taste and Burning Sensation: Patients often report changes or loss of taste (ageusia or dysgeusia), accompanied by burning sensations in the tongue or oral mucosa, contributing to mouth pain.
Possible Causes of Mouth Pain in COVID-19/Mouth Pain Covid –

Since the emergence of COVID-19, caused by the SARS-CoV-2 virus, a spectrum of symptoms has been reported, ranging from respiratory difficulties to neurological issues. Among these, mouth pain or oral discomfort has been observed in some patients, raising questions about its underlying causes. Understanding the possible reasons for mouth pain in COVID-19 /Mouth Pain Covid can help patients and healthcare professionals manage these symptoms more effectively.
1. Direct Viral Infection of Oral Tissues
The SARS-CoV-2 virus uses the ACE2 receptor to enter human cells. These receptors are abundantly present in the oral mucosa, particularly on the tongue and salivary glands. This suggests that the virus can directly infect and damage oral tissues, leading to inflammation, ulcers, and pain. Some COVID-19 patients report a burning sensation or soreness in their mouth, which may be linked to this direct viral invasion.
2. Secondary Infections
COVID-19 can weaken the immune system, making patients susceptible to secondary infections such as oral candidiasis (thrush) or herpes simplex virus reactivation. These infections can cause painful sores, redness, and irritation within the mouth. Additionally, the use of steroids or antibiotics during COVID-19 treatment can further predispose individuals to such infections, contributing to mouth pain.
3. Cytokine Storm and Inflammatory Response
Severe COVID-19 cases often involve a hyperactive immune response known as a cytokine storm. This systemic inflammation can affect multiple organs and tissues, including the oral cavity. The increased inflammation may lead to mucosal irritation, swelling, and pain in the mouth. Even in milder cases, localized inflammatory responses could contribute to discomfort.
4. Dehydration and Dry Mouth
Fever, reduced fluid intake, and breathing through the mouth due to nasal congestion can cause dehydration and xerostomia (dry mouth) in COVID-19 patients. Saliva plays a crucial role in lubricating and protecting oral tissues; insufficient saliva can result in soreness, cracking, and sensitivity, which manifest as mouth pain.
5. Side Effects of Medications
Medications commonly used to treat COVID-19 symptoms, such as antiviral drugs, antibiotics, or pain relievers, may have side effects that affect the oral cavity. For example, some drugs can cause mucositis (inflammation of the mucous membranes), taste disturbances, or ulcers, contributing to mouth pain.
6. Stress and Anxiety
The psychological impact of COVID-19, including stress and anxiety, can lead to behaviors such as teeth grinding or jaw clenching (bruxism), which may cause muscular pain around the jaw and mouth. Additionally, stress can exacerbate conditions like aphthous ulcers (canker sores), intensifying mouth discomfort.
7. Nutritional Deficiencies
Illness-related poor appetite or malabsorption can cause deficiencies in vitamins and minerals like B-complex vitamins, iron, or zinc. Such deficiencies often manifest as painful oral lesions or glossitis (inflammation of the tongue), further contributing to mouth pain.
How to Treat Mouth Pain in COVID-19/Mouth Pain Covid

Mouth pain is an often overlooked but significant symptom experienced by some individuals with COVID-19. This pain can manifest as sore throat, mouth ulcers, burning sensations, or general discomfort inside the mouth. Understanding how to manage and treat mouth pain during COVID-19 is essential to improve comfort and aid overall recovery.
Managing and Treating Mouth Pain

- Maintain Oral Hygiene:
Keeping the mouth clean is critical to reduce irritation and prevent secondary infections. Use a soft-bristled toothbrush and brush gently twice daily. Rinse the mouth with a mild, alcohol-free antiseptic mouthwash or a saline solution made by dissolving half a teaspoon of salt in a glass of warm water several times a day. - Stay Hydrated:
Drink plenty of fluids to keep the mucous membranes moist. Avoid very hot or acidic beverages that can worsen irritation. Sipping water regularly can also soothe dry mouth. - Pain Relief:
Over-the-counter pain relievers such as acetaminophen (paracetamol) or ibuprofen can help alleviate mouth pain and reduce inflammation. Always follow the recommended dosages and consult a healthcare provider if unsure. - Topical Treatments:
Over-the-counter topical gels or sprays designed for mouth sores can provide localized pain relief. Some contain numbing agents like benzocaine, but use them sparingly and according to instructions. - Avoid Irritants:
Avoid tobacco, alcohol, spicy, salty, and acidic foods as they may exacerbate pain and delay healing. - Nutritional Support:
A balanced diet rich in vitamins, especially vitamin C and B-complex vitamins, supports mucosal healing. Soft, bland foods can minimize discomfort while eating. - Monitor for Secondary Infections:
If you notice white patches (possible thrush), severe ulcers, or persistent worsening pain, contact a healthcare professional. Antifungal or antibiotic medications might be necessary.
When to Seek Medical Advice
Seek immediate medical attention if mouth pain is severe, accompanied by difficulty swallowing or breathing, high fever, or if symptoms persist beyond two weeks. These could indicate complications or the need for specialized care.
Conclusion
Mouth pain in COVID-19 can arise from multiple interrelated causes, including direct viral effects, secondary infections, inflammation, dehydration, medication side effects, psychological stress, and nutritional deficiencies. Recognizing these possibilities is essential for proper diagnosis and management. If mouth pain occurs during or after a COVID-19 infection, consulting healthcare professionals can help identify the cause and recommend appropriate treatment to alleviate discomfort and promote healing.
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